Overweening Generalist

Showing posts with label hot peppers. Show all posts
Showing posts with label hot peppers. Show all posts

Saturday, May 14, 2016

Updates and Re-Takes On Some Old Posts: Toxo, Hot Peppers and Boredom

A. Toxoplasmosis 
I had written a bit on Toxoplasmosis gondii  HERE. This is a weird microbe that infects around 11% of Unistatians and other countries have a much higher infection rate. If infected by this parasite, most people's immune systems keep it in check; for others it appears to get into the brain, cause cysts there (Ew!), and very weird stuff: it makes women more aggressive; men become more impulsive and less fearful when they probably should be cautious. One way we get it is via contact with domesticated cat feces. It rarely kills anyone; it simply makes them act strangely.

Right after I wrote about it, another study came out. (Secondhand HERE.) Its lead author, E.Fuller Torrey, thinks cats should be seen as more dangerous than most of us think they are. Having a cat around in your childhood might lead to schizophrenia or other mental illness in adulthood, their study suggests.

Sidelight: Interestingly to sombunall readers of this blog, Dr. Torrey published a book on Ezra Pound in 1984; I've read it: Torrey thinks Pound and his pals in high places got away with pulling a fast one on the Unistat gummint: Pound was found, basically, insane for broadcasting his at-times vile antisemitic thoughts over the radio with Mussolini's imprimatur, and therefore Pound avoided a death sentence for treason.

Adding to this bizarre infection, a study in France sought to understand the possible evolutionary aspect of Toxo. Some chimps were infected with it, and urine from a leopard didn't scare them away like it should have. Today, mice and rats infected with Toxo aren't afraid of domesticated cats like they ought to be, for their own survival. I also learned that lions and tigers are not predators of chimps, but leopards are. I will never become a zoologist at this point...

Stanford biologist Robert Sapolsky is fascinated by the Toxo research, while his equally brilliant colleague at Stanford's rival, U. of California at Berkeley, Michael B. Eisen, said this study is interesting, but the chimps' sense of smell could be set off by factors other than their Toxo infection.

So: Toxo may have jumped from being incubated in the guts of a Big Cat, to domesticated cats circa 15,000 years ago. But I don't see the evolutionary Big Picture of Toxo, other than it's doing what it's got to do to keep going generation after generation, like viruses. It makes some of us act really weird, and humans in our pre-history who ended up being eaten by big cats? They're not any of our ancestors. I'd like to hear an Intelligent Design person explain this one.

B. On Hot Peppers
Three and a half years ago I blogged about, among other things, my love for very hot peppers, and how I might have hallucinated in a Thai restaurant near Berkeley due to an extreme hot pepper event. I still chase after the buzz, and the quest to develop the hottest peppers in the world continues unabated.

Recently I ran across a fascinating article by a Berkeley writer (who I only know by name), Andrew Leonard. "Why Revolutionaries Love Spicy Food: How the Chili Pepper Got To China."

Now, I consider Nautilus one of the best online magazines, but the comments for this article were, I thought, really horrid. So many fine points made by Leonard missed! (Also: Leonard invites semantic reaction by asserting that "revolutionaries" like really hot peppers, when he really only makes a strong case for those Chinese coming out of Sichuan Province.) Was George Washington a lover of hot peppers? Doing the research: no. Karl Marx? Probably not. Che? He appears to have liked spicy food, but he didn't make a huge deal out of it. One of the highlights of Leonard's piece is the story of how former German schoolteacher Otto Braun, turned Soviet counter-espionage agent, was sent to advise Mao, and couldn't get used to the very spicy food, and Mao is quoted, "The food of the true revolutionary is red pepper."



U. of Pennsylvania psychologist Paul Rozin had long been interested in why some people really love hot, spicy foods and peppers. Why do peppers seem "hot" when they aren't? Because capsaicin activates pain receptors (called TRPV1) for actual hot things. It's a delightful glitch, methinks. Rozin thought people attracted to hot peppers and who enjoy the taste and the pain must be the same sorts of people who are thrill-seekers, chance-takers...maybe even revolutionaries? Mao thought the pepper-lover is ready to fight and win; Rozin later coined the term "benign masochism" for pepper-lovers.

(So who are the malignant masochists? Poor Trump supporters?)

Decades after Rozin's guesses about hot pepper-lovers, research has validated his ideas. A Penn.State study showed a significant correlation between "sensation seeking" and love for hot peppers. (Italics mine to remind you it's tentative.)

Leonard goes into the history of Sichuan Province: where, about 250 years after Columbus, hot peppers made their way and grew easily and cheaply and preserved themselves for long periods and added flavor to dishes, vitamins B and C, and were antibacterial to boot.

The history of Sichuan and its de-population in the 16th century due to banditry, famine and rebellions, followed by an influx of 1.7 million the next century (fall of the Ming, rise of the Qing) is one Leonard tries to tie with the hot and humid province, the ying/yang medicinal philosophy, the cheapness of raising hot peppers there, and risk-taking personalities on the move due to internal strife. Because these hardy souls lived through tough times and migrated to Sichuan from other parts of China, the idea is that revolutionary personalities are prevalent there. And hey, I dig a spicy-food-loving lady too. But the neurobiological research so far shows that these pepper-lovers may just be more thrill-seeking; I think political revolutionary is a mere sub-type. Still, read the article, 'cuz it's pretty good if you're into that sorta thing.

It seems people are probably not born with a penchant for spicy hot peppers, and need to become habituated. I think I habituated myself, and it could be because I'm what Linda Bartoshuk calls a "nontaster": the number of fungiform papillae on my tongue make me like my coffee black and strong, my beer very hoppy and bitter, my peppers really hot, etc. However, I have never considered myself a thrill-seeker in the ordinary sense of the term. I do seek novelty...



C. On Boredom
I assayed some aspects - mostly my subjectivity - toward boredom HERE. With the availability heuristic - or is it more like "priming"? - once I've written on some topic, that topic suddenly appears everywhere.

A book called Unbored came to my attention. Although it's for younger people, I saw a lot of my own thinking on the topic reflected there. In delving into Robert Anton Wilson's Sex, Drugs and Magick, looking for a reference about something else, I happened to re-read a part of RAW's discussion of Aleister Crowley's book Diary of a Drug Fiend:

In the third, and most controversial part of the book, "Purgatorio", Peter and Lou attempt a cure under the auspices of a mysterious magician named King Lamus - a thinly disguised portrait of Crowley himself. At the Abbey of Thelema (based on an actual religious retreat once run by Crowley in Sicily), Peter and Lou are put in a situation where all the cocaine and heroin they could possibly want is immediately and easily available to them. King Lamus tells them, using Crowley's favorite slogan, "Do what thou wilt shall be the whole of the law."

There is a gimmick, of course. In fact, there are several gimmicks. The abbey, although hardly as austere as a Christian monastery, is quite isolated from civilization; Peter and Lou are soon confronted with the most underrated but powerful force in the world - boredom. There are no movies, nightclubs, or other distractions. When they complain, King Lamus tells them again, "Do what thou wilt shall be the whole of the law." They soon discover that, in spite of their hedonistic existence, they have never actually done their "will" in a profound sense, but have only followed momentary whims. Isolated at the abbey, they are forced to ask themselves, again and again, what they truly do "will" for their subsequent lives.
-p.186

Take a few moments to ponder this?

Boredom is being tackled by neuroscientists: if you've ever been tackled by a neuroscientist, you know what I mean. But I jest. Scientist Bill Greisar says of boredom that it's so pervasive it "suggests it serves some critical role in behavior." Which I think Crowley - a more interesting psychologist to my eyes - saw in the early part of the century. In one of many articles on boredom studies, Ingmar Bergman's Scenes From A Marriage comes up, as does Dickens, and the idea of one thinker that boredom is a milder form of disgust, which took me some time to "see." (Right now, I've gone back to not "seeing" much of a relationship between Boredom and Disgust, and I'm afraid it simply was never meant to be. I'd like to fix up Boredom with Anger...)

Many studies have shown that boring activities lead to more creativity, even boring reading activities. ("In some circumstances" was the caveat from one researcher.)

In a creative activity bored subjects performed better than distressed, elated and relaxed subjects. (I wonder how they provoked elation?) The physiology of boredom is interesting: you're more stressed (cortisol in bloodstream), with an increased heart rate, unmotivated by your surroundings, and have a difficult time sustaining attention.

What could be the purpose of boredom? A Texas A&M study suggests boredom is something like hunger or thirst: it motivates you to change your immediate circumstances. You seek novelty, new goals and situations. "By motivating desire for change from the current state, boredom increases opportunities to attain social, cognitive, emotional and experiential stimulation that could have been missed." Anticipation of a change in mental state is associated with our old pal Dopamine.

Philosopher Andreas Elpidorou says boredom is essential for a decent life and life without it would be a nightmare.

Around the same time, I stumbled upon the idea that, how can we still be bored in the 21st century? The idea is that too much stimulation is boring.

Since my initial blog on boredom, I've become convinced that I do get bored. It's probably not true of my assertion that I'm never bored. It's a matter of degree, which reduces to the felt amount of time bored, which for me isn't much. Id est: my moments of boredom are so brief, I don't frame them as "me being bored." I simply move on to the next thing. And there are endlessly interesting things of easy avail to me. Perhaps I'm some sort of intelligent simpleton?

I consider my lifetime love of reading here paramount. How many departures from my paramount "reality" are available to me in books? It's endless. It's good for a reliable squirt of dopamine into my brain-pan.

Not long ago I read a wonderful novella by Anton Chekhov, The Story of a Nobody, from around 1893. The description of the main male antagonist's friend, a logical man named Pekarasky, who can multiply two three-digit numbers in his head immediately, has railway and finance tables memorized, can convert currencies mentally and accurately:

But for this extraordinary intelligence many things that even a stupid man knows were quite incomprehensible. Thus he could not understand at all why it is that people get bored, cry, shoot themselves and even kill others, why they worry about things and events that do not affect them personally, and why they laugh when they read Gogol or Saltykov-Schedrin. 
-p.11

Is this not a creepy guy, this Pekarsky? Doesn't something about him seem vaguely monstrous to you?

Walker Pearcy's theory of hurricanes seems to fit in here nicely. Malaise and despair and world-weariness can be fixed by a you-must-act-now situation, which is the hurricane. My view is that we need to pay attention and develop a mental "patch" so that it doesn't require a hurricane or car accident in order to make our interiorities vital again.

                                           kunst: Mr. Bob Campbell

Tuesday, November 27, 2012

Drug Report for November, 2012: Jimi Hendrix, CalTech, Ultra-Hot Chili Peppers, A Gorgeous Female Film Star

Well, it's Jimi Hendrix's birthday - he was the Seattle Sound 1.0 - and Jimi was whipping his Fender Strat around onstage, catching the harmonic feedback at just the right moment, dive-bombing it with the whammy, then ripping a blues lick with a wicked vibrato, while picking with his teeth...before violently smashing his axe through his Marshall stack, then burning the thing, all while Kurt Cobain was in diapers. Kurt was three when Jimi ODed on Vasparax (sleeping pills) and red wine...Jimi would've been 70 today. In some Universe Next Door he's still alive and has recorded three totally killuh albums with Jeff Beck. Kurt would be alive there too. Hey why not?

FREE CalTech Class: Drugs and the Brain: Starts December 1st:
I know this is late notice, and I'm personally passing on this one, but you can take a free course at Coursera called Drugs and the Brain; it's the first class you take in Neuroscience when you go to the true Left Coast "genius" school. (MIT is the Right Coast one.) Henry A. Lester is a heavyweight and the class will go from December 1st, for five weeks, will take 4-6 hours a week of your precious time, and it's - fair warning - a gateway drug to more neuroscience. Lester can probably tell you, extempore, in garish detail, what happens when you take the same cocktail of drugs Jimi took that horrible night, presumably telling us way too much about dying by inhaling your own vomit, but then I've got my digression out of the way...

Red Hot Chili Peppers: the Food, Not the Band
Although: Flea of the RHCP has a Hendrix tattoo.
Full disclosure: the OG is a spicy food fiend, and I will try the hottest salsa or curry that comes my way, and one time I had a bona fide weird experience with something so hot, so spicy, I probably couldn't handle it, which I'll get to momentarily.

Columbus's crew encountered the new world chile "peppers" (a misnomer: that's all they could compare it to); previously it was unknown what the actual response was to eating one of the hottest ones the natives had, but recently I unearthed some lost documents, and Columbus himself is recorded as being handed one by a native, Columbus looks at its bright red color and says in Italian to his friends, "What's the worst it can do? Give me the squirts? It's not like we don't have that every day on the Santa Maria, eh boys?" The parchment records that that line killed, much laughter was heard. Then Columbus took a bite, started to remark on its texture and not-unpleasant flavor, how King Ferdinand might like it, then, suddenly, "Sweet Isabella's netherparts! That's some molten demon fruit! Christ, my tongue's got a Mount Aetna situation here boys! Watch yourselves! This may be a trick...HOLY!...it keeps creepin' up on ya, like a horny galleymate after two months at sea. Someone give me a glass of water, stat! Then begin enslaving these godless heathens for the next, oh, let's make it 400 years." (My translation)

What Columbus didn't know - no one knew, apparently, was that if he just smoked a huge bomber of some nearby cannabis, it would've alleviated the pain. Don't believe me? (You have every reason to suspect I'm bullshitting you after that above paragraph, I don't blame you.) Check out this study.

Are we cool now? (No?)

                              Baskets of chili peppers at a market in Oaxaca, Mexico.
                              Like Pavlov's dog, my mouth begins to water just seeing them

Pharmacagnosy of Blazing Hot Peppers
You eat something with a real spicy pepper kick. The chemicals in peppers that give the effects are called capsaicinoids. They hit the tongue and stimulate the vanilloid subtype 1 nerve receptors in the mouth, throat, anything nearby that's nasal. When these receptors are activated, evolution has made us perceive this as "heat," although there's nothing hot about the capsaicinoids, temperature-wise. It's probably an evolutionary protective effect. Anyway: the perception of heat releases a neuropeptide called Substance P, which says to the body's systems, "We got some pain INCOMING!" Substance P gets into the brain, binds to opioid receptors, and the brain releases its own endogenous morphine, called endorphins. (Thank you, scientific goddess Candace Pert!)

Minor encounters with really hot peppers: reports of euphoria, clarity of mind, sweating. I must have had something really strong, which I'll get to later.

Wilbur Scoville
In 1912, Wilbur Scoville, trying to develop a drug using capsaicin for muscle aches, invented a method for measuring how hot certain peppers were. Ingeniously, he had people eat certain peppers, then he measured how much sugary water it took to douse the pain. The more sugar water required, the hotter the pepper. If 3 out of 5 volunteers said they were good to go, let's bring on the next pepper, then Scoville recorded his data. What I like about Scoville is that he used organoleptic methodology: actual human beings reporting phenomenologically the effects the drug (capsaicin, in this case) had on them. The Scoville Scale is still used, although now a highfalutin' High Pressure Liquid Chromatography gauge has been developed, which directly measures capsaicin. But no organoleptic methodology, so...

Peppers are still measured in Scoville Heat Units, and the Naga Jolokia pepper of India has 855,000 SHUs. The average jalapeno? A mere 5000 SHUs, ya pussy. 'Smatter? Can't you handle it? Go ahead, try a Naga Jolokia, plain. I dare ya.

Going For The Record
Trying to determine what the hottest pepper is in the world is not easy. The people at Guinness are interested. The competition is hot...uhhh...fierce. An article from NPR in 2011 has Ed Currie (apparently his real name) of So. Carolina, and a major pepper freak who originally got into the game because he heard capsaicin fights cancer, which he has a lot of in his family, developing a pepper that apparently was going to measure 1.5million SHUs, breaking the Trinidad Scorpion's 1.4 million SHUs. Currie bragged that 2 of 3 people who ate his pepper vomited. Good job, Currie! And thanks for bringing the world record back to us. USA! USA! USA! (Currie is marketing his stuff under the Pucker Butt Pepper Company. Stay classy, Ed.) And if you doubt the overwhelming power of megahot peppers, watch the video embedded in the NPR link I gave at the beginning of this paragraph. If it does fight cancer, it looks like some sorta chemotherapy itself, doesn't it? Moving on...

However, a 2012 article in Time has the Trinidad Moruga Scorpion as the hottest in die welt, at 1.2 SHUs. Something seems amiss, and a decent reporter would get to the bottom of this by contacting the Guinness people, but I am not decent. I'm in a ratty old sweatshirt, and I'm goin' "commando." I am not your man. Let us be happy that the race is on to make the asphalt on a lone Texas highway buckle under the latest, hottest chili peppers. Someone has to do it!

Effects of Uber-Hot Peppers
The heart rate goes up and you sweat a lot. You feel mentally and physically stimulated. You're giddy, euphoric and one guy in the hot pepper biz says you get a "crack-like rush." This is all legal, for now. Many ingesters have reported dissociative thoughts. In this it's like DMT, which you use and you're gone, even sitting among your friends. And both DMT and very very hot peppers can make you feel "gone" for 5-20 minutes. Then it clears. (Kids: DMT has a few whole Other dimensions to it, and I meant that capital O very seriously. Watch it! Read up on it first. It's a very intense psychedelic experience.)

Dr. Andrew Weil has advocated "mouth surfing" in order to get high and/or use in lieu of Vicodin. This involves using really hot peppers, titrated, calculatedly in a continuous ingestion for a long-term endorphin rush. I have done this once, and it was only half-calculated.

                                      mouth-wateringly gorgeous Angelina Jolie, a main 
                                      player in one of my own psychoactive drug trips
                    
My Weird Hot Pepper Experience
I'm sitting with my wife in a booth in our favorite Thai restaurant, in Albany, California. (Since closed: sigh) I always order the chicken red curry, "extra spicy." Sometimes it's really, really hot and I get a nice endorphin buzz, I'm ebullient, new ideas flow, I'm glib - I'm also drinking Thai beer - and it's just one of life's simple pleasures. Maybe you have friends like me: I'm the guy my friends dare to eat "that pepper, plain," and I do it. Do I often feel pain? Of course. But also: the opiate buzz.

So: we're sitting against the back wall and I'm facing a corner booth that's empty. We order. I ask for the same thing I always get, but since the last time we were there, I'd learned a Thai phrase, "mak-mak," which means "Thai spicy-hot," basically. So: there's "hot" for people of European descent, then there's a "Thai hot." When I said this, I distinctly remembered the waitress's pupils double in size and she asked, "You sure?" I said yea, of course. I mean, how much hotter could it be?

Hotter than anything I'd ever had in my life. I was a quarter way through and in pain. I was amazed at the heat. Sweat immediately pooled at the back of my neck, then ran down my spine, noticeably. I had to wipe my brow every two minutes, as if I'd been digging ditches at high noon in Tombstone, Arizona. But I was also starting to feel the high, so I was enjoying myself. Sips of beer or ice water did nothing to attenuate the fire roaring in my mouth, but our conversation was pleasant, even if my wife interrupted with, "Are you alright?" When curry is this hot, it's not a meal, it's an event. Hey, I'm a tough guy when it comes to hot peppers. Everyone knows this. Don't worry about it.

Then a couple came in and sat in the corner booth, a man and a woman. The woman faced me while the man's back was to my wife's back. I made eye contact with the woman who was quite beautiful. She was with an older man who had a ponytail and reminded me of Hollywood producer-type guys. She looked uncannily like Angelina Jolie. My wife and I kept our conversation going. The waitress came over to ask if I was okay. I said this was the hottest curry I've ever had, and...uhh...bravo! She told me that if things were too hot I should swallow a packet of sugar or two. I was going to say no, but thought, hey, it's maybe not a bad idea. I made eye contact with the woman again, and quickly I was convinced it was Angelina Jolie. But why would she be in a relatively out-of-the-way Thai restaurant on San Pablo in Albany? I leaned over and whispered to my wife that I think Angelina Jolie was sitting facing me, and to eavesdrop in order to hear what they're talking about. I poured two packets of sugar on my tongue and kept eating, knowing that I was acting crazy but this was all too weird and exciting. I wiped my brow. Angelina smiled at me. Those bee-sting lips! Those cheek bones! She was covered up with a white jacket with feathery-fringe around the neck because it was a rainy night and cold, wind whipping up off the San Francisco Bay.

My wife said she was going to the ladies' room, so that when she came back she could get a good look at "Angelina." Ms. Jolie and I made eye contact a couple of times. Should I wave hello? Is this "mak-mak" red curry so hot I'm hallucinating Angelina Jolie? I tried to remain cool, but my face was sweating. My wife came back, got a good long look at Angelina, then, after 20 seconds, leaned over and whispered, "It looks a lot like her, but I think it's someone else." I was both disappointed at her report and vaguely relieved. Meanwhile, I had heard a report earlier in the day on the economics of micro-lending to poor people in Africa. Someone had won the Nobel Prize in Economics for the idea, and the idea was big in Berkeley, especially at the university. And I had told myself, Angelina's in town to learn more about micro-lending; she's adopted all those Third World kids. She cares. It makes sense!

All my friends have laughed when I told them this story. I have pretty much convinced myself it wasn't her, mostly because I did some research on plastic surgery and how common it is for people with too much money (and maybe values I don't subscribe to?) to get five, seven, 15 "upgrades" (this is the term I saw used over and over) over the course of their lives. And there are some women who actually try to look like celebrities, and Angelina is a hot item. My guess is I was sitting across from some gal who had tried her best to look like Ms. Jolie, and combined with the psychoactive properties of that nuclear red curry, I had had one helluva weird and memorable 40 minutes.

Further Items
Capsaicin may help with weight loss.

Here's a report on my favorite blazing hot salsa, available where I live, Happy Jackal's Hell-Fire from fellow blogger Isoceleria. Other scorching salsas I've read about: "Endorphin Rush" and "Molten Lava."

Why do astronauts begin to crave hot, spicy food, Tabasco and peppers when they go into space, even they didn't like spicy foods on Earth?

The Mayans used hot peppers as chemical warfare: they burned them upwind from their enemies. Of course, Pepper Spray is derived from capsaicin, so James Pike's spiritual descendants are the Mayans. Go figure.

Here's Hendrix playing "Killing Floor" at Monterey: